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Report error Found 1171 Enz. Inhib. hit(s) with Target = 'Thyroid hormone receptor beta'
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM36487(CHEMBL263630 | CO23)
Affinity DataKd:  1.70nMAssay Description:Thyroid hormone competitive binding assay using TNT T7 quick-coupled transcription translation system from promega.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM36488(CO22)
Affinity DataKd:  280nMAssay Description:Thyroid hormone competitive binding assay using TNT T7 quick-coupled transcription translation system from promega.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.0810nMAssay Description:Thyroid hormone competitive binding assay using TNT T7 quick-coupled transcription translation system from promega.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  11nMAssay Description:TRE-driven dual-luciferase reporter assay in human bone osteosarcoma epithelial (U2OS) cell line.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM36487(CHEMBL263630 | CO23)
Affinity DataEC50:  390nMAssay Description:TRE-driven dual-luciferase reporter assay in human bone osteosarcoma epithelial (U2OS) cell line.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM36487(CHEMBL263630 | CO23)
Affinity DataEC50:  58nMAssay Description:TRE-driven dual-luciferase reporter assay in human uterine cervical cancer (Hela) cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  2.40nMAssay Description:TRE-driven dual-luciferase reporter assay in human uterine cervical cancer (Hela) cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.0810nMAssay Description:Human thyroid hormone receptor alpha and beta (hTR alpha1) and (hTR beta1) were produced using TNT coupled reticulocyte lysate system from Promega.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataKd:  0.0670nMAssay Description:Human thyroid hormone receptor alpha and beta (hTR alpha1) and (hTR beta1) were produced using TNT coupled reticulocyte lysate system from Promega.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50130595(Dimethyl-isopropyl-T3 (DIMIT) | CHEMBL105983 | 2-A...)
Affinity DataKd:  9.80nMAssay Description:Human thyroid hormone receptor alpha and beta (hTR alpha1) and (hTR beta1) were produced using TNT coupled reticulocyte lysate system from Promega.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataEC50:  62nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012817(CHEMBL3261330 | USRE46024, 19)
Affinity DataEC50:  6.98E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012859(CHEMBL3261319 | USRE46024, 2)
Affinity DataEC50:  7.01E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012902(CHEMBL3261318 | USRE46024, 1)
Affinity DataEC50:  7.75E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012904(CHEMBL3261329)
Affinity DataEC50:  9.17E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012903(CHEMBL3261328 | USRE46024, 17)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012910(CHEMBL3261326 | USRE46024, 14)
Affinity DataEC50:  2.99E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012901(CHEMBL3261320 | USRE46024, 4)
Affinity DataEC50:  2.38E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012913(CHEMBL3261333 | USRE46024, 16)
Affinity DataEC50:  40nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012907(CHEMBL3261336 | USRE46024, 13)
Affinity DataEC50:  90nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012914(CHEMBL3261325)
Affinity DataEC50:  120nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012915(CHEMBL3261335 | USRE46024, 9)
Affinity DataEC50:  120nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012908(CHEMBL3261334 | USRE46024, 22)
Affinity DataEC50:  140nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012905(CHEMBL3261331 | USRE46024, 8 | US20240059676, Comp...)
Affinity DataEC50:  210nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012911(CHEMBL3261332 | USRE46024, 12)
Affinity DataEC50:  220nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012912(CHEMBL3261321 | USRE46024, 3)
Affinity DataEC50:  460nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012917(CHEMBL3261327 | USRE46024, 15)
Affinity DataEC50:  600nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012918(CHEMBL3261324 | USRE46024, 6)
Affinity DataEC50:  670nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012916(CHEMBL3261322 | USRE46024, 5)
Affinity DataEC50:  700nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50012906(CHEMBL3261323 | USRE46024, 10)
Affinity DataEC50:  770nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50105669({4-[1-(4-Hydroxy-3-isopropyl-phenyl)-but-3-enyl]-3...)
Affinity DataKd:  90nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR beta 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50105670({4-[11-(Butyl-methyl-carbamoyl)-1-(4-hydroxy-3-iso...)
Affinity DataKd:  148nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR beta 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50105668({4-[11-(Butyl-methyl-carbamoyl)-1-(4-hydroxy-3-iso...)
Affinity DataKd:  720nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR beta 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.140nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR beta 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50105667({4-[4-Hydroxy-1-(4-hydroxy-3-isopropyl-phenyl)-but...)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR beta 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50105671({4-[(2,4-Dimethoxy-phenyl)-(4-hydroxy-3-isopropyl-...)
Affinity DataKd:  4.20E+3nMAssay Description:Binding affinity towards thyroid hormone receptor (hTR beta 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18884(CHEMBL112087 | JMC496635 Compound 4 | 2-(4-{[4-hyd...)
Affinity DataKd:  35nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18885(JMC496635 Compound 5 | 2-[4-({4-hydroxy-3-[2-(4-ni...)
Affinity DataKd:  20nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  2nMAssay Description:Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115666({4-[4-Hydroxy-3-isopropyl-5-(4-pentyl-phenylethyny...)
Affinity DataKd:  0.520nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataEC50:  7nMAssay Description:Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115666({4-[4-Hydroxy-3-isopropyl-5-(4-pentyl-phenylethyny...)
Affinity DataEC50:  380nMAssay Description:Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115667([4-(4-Hydroxy-3-isopropyl-5-phenylethynyl-benzyl)-...)
Affinity DataKd:  37nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115668([4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phe...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115667([4-(4-Hydroxy-3-isopropyl-5-phenylethynyl-benzyl)-...)
Affinity DataEC50:  500nMAssay Description:Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of California San Francisco

LigandPNGBDBM50115669({4-[3-(4-Amino-phenylethynyl)-4-hydroxy-5-isopropy...)
Affinity DataKd:  90nMAssay Description:Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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