Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 2'
LigandPNGBDBM50575835(CHEMBL4878260)
Affinity DataIC50: 13nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux pretreated for 30 se...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 210nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 210nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux after 30 to 60 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 320nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Rat)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 330nMAssay Description:Inhibition of TRPM2 in rat INS-1 cells assessed as reduction in ADPR-induced intracellular calcium flux measured after 60 mins by whole cell patch cl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575838(CHEMBL4863360)
Affinity DataIC50: 398nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575841(CHEMBL4864346)
Affinity DataIC50: 410nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575839(CHEMBL4856222)
Affinity DataIC50: 467nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM27502(CHEMBL127336 | 3,4-dihydro-5-(4-(1-piperidinyl)but...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux pretreated for 30 se...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575837(CHEMBL4863549)
Affinity DataIC50: 788nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575836(CHEMBL4849043)
Affinity DataIC50: 830nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50575840(CHEMBL4856093)
Affinity DataIC50: 987nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux by whole cell patch clamp electr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux after 30 mins by Fluo4-AM dye ba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50291511(2-((E)-3-Biphenyl-4-yl-acryloylamino)-benzoic acid...)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM31773(ECONAZOLE | cid_68589 | Pevaryl | Gyno-pevaryl | E...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM31774(cid_2812 | CHEMBL104 | Canesten | Mycelex | Lotrim...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50405913(CHEMBL4176916)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50405913(CHEMBL4176916)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50405912(CHEMBL4159037)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux at 0 mV holding potential by who...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50405910(CHEMBL4174768)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50405911(CHEMBL4167784)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced channel currents treated extracellularly after 60 secs by w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50579155(CHEMBL4872096)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50579154(CHEMBL4873412)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50450500(CHEMBL4164465)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRPM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50446561(CHEMBL3110215)
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at TRPM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50446559(CHEMBL3110213)
Affinity DataIC50: 4.90E+4nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50446560(CHEMBL3110214)
Affinity DataIC50: 5.10E+4nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50385713(CHEMBL23479)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50446557(CHEMBL3110204)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50446558(CHEMBL3110195)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50324670(5'-O-[N-(salicyl)-sulfamoyl]-adenosine | 5'-O-[N-(...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50446562(CHEMBL3110216)
Affinity DataIC50: 3.00E+5nMAssay Description:Antagonist activity at human TRPM2 expressed in HEK293 cells assessed as inhibition of ADPR-induced maximum outward potassium current at +15 mV by wh...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed