Report error Found 274 Enz. Inhib. hit(s) with Target = 'Trifunctional purine biosynthetic protein adenosine-3'
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Pennsylvania State University
Curated by ChEMBL
Pennsylvania State University
Curated by ChEMBL
Affinity DataKd: 0.25nMAssay Description:Thermodynamic dissociation constant (KD) was measured upon binding to GAR TFase in miceMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0nMAssay Description:Inhibition of the GAR transformylase in lactobacillus caseiMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR formyl transferase in lactobacillus caseiMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR formyl transferase in lactobacillus caseiMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of the GAR formyl transferase in lactobacillus caseiMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of the GAR transformylase in MOLT-4 human leukemia cellsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Pennsylvania State University
Curated by ChEMBL
Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of the GAR formyl transferase in L1210More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Pennsylvania State University
Curated by ChEMBL
Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of the GAR formyl transferase in L1210More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 0.950nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.79nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of GARFTase in human KB cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs by ion-exchang...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as decrease in incorporation of [14C(U)glycine into [14C]formyl GAR formation after 24 hrsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.03nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as incorporation of [U-14C]-glycine into [14C]-formyl glycinamide ribon...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 3.46nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assayMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as decrease in [14C]formyl GAR accumulation preincubated for 30 mins followed by [14C]glycine addit...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 5.77nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 6.60nMAssay Description:Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR ...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 7nMpH: 7.5Assay Description:GARFTase activity was determined by measuring the rate of 5,8-dideazatetrahydrofolate production in the presence of varying concentrations of antifol...More data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
University of South Alabama
Curated by ChEMBL
University of South Alabama
Curated by ChEMBL
Affinity DataIC50: 9nMpH: 7.5Assay Description:GARFTase activity was determined by measuring the rate of 5,8-dideazatetrahydrofolate production in the presence of varying concentrations of antifol...More data for this Ligand-Target Pair
