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Report error Found 21441 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1'
TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd: >1.00E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  280nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  65nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  37nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633261(US20190276450, Example 1)
Affinity DataEC50:  5.45E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633263(US20190276450, Example 1.2)
Affinity DataEC50:  1.35E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633264(US20190276450, Example 1.3)
Affinity DataEC50:  1.00E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633266(US20190276450, Example 1b.2)
Affinity DataEC50:  2.10E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633267(US20190276450, Example 1b.3)
Affinity DataEC50:  4.46E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633268(US20190276450, Example 1b.4)
Affinity DataEC50:  7.60E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633269(US20190276450, Example 1b.5)
Affinity DataEC50:  1.50E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633270(US20190276450, Example 1b.6)
Affinity DataEC50:  4.20E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633271(US20190276450, Example 2)
Affinity DataEC50: >4.00E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633273(US20190276450, Example 2.2)
Affinity DataEC50:  4.10E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633274(US20190276450, Example 2.3)
Affinity DataEC50:  1.80E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633280(US20190276450, Example 2.8)
Affinity DataEC50:  1.70E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633283(US20190276450, Example 2.11)
Affinity DataEC50:  7.50E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633286(US20190276450, Example 2a.3)
Affinity DataEC50:  5.60E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633288(US20190276450, Example 3)
Affinity DataEC50:  1.80E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633289(US20190276450, Example 3.2)
Affinity DataEC50:  3.40E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >1.00E+5nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633293(US20190276450, Example 4.3)
Affinity DataEC50:  5.40E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633295(US20190276450, Example 5)
Affinity DataEC50: >1.00E+5nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633296(US20190276450, Example 5.2)
Affinity DataEC50: >1.00E+5nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633298(US20190276450, Example 6)
Affinity DataEC50:  2.10E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633299(US20190276450, Example 6.2)
Affinity DataEC50:  5.20E+3nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633301(US20190276450, Example 7)
Affinity DataEC50:  3.40E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633302(US20190276450, Example 8)
Affinity DataEC50:  2.20E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633303(US20190276450, Example 9)
Affinity DataEC50:  4.20E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633304(US20190276450, Example 10)
Affinity DataEC50:  2.70E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633305(US20190276450, Example 11)
Affinity DataEC50:  2.30E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633308(US20190276450, Example 12)
Affinity DataEC50:  1.62E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633310(US20190276450, Example 12.3)
Affinity DataEC50:  1.30E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633312(US20190276450, Example 12.5)
Affinity DataEC50:  2.00E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633313(US20190276450, Example 12.6)
Affinity DataEC50:  1.50E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633314(US20190276450, Example 12.7)
Affinity DataEC50:  1.50E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633316(US20190276450, Example 12a.3)
Affinity DataEC50: >1.00E+5nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633317(US20190276450, Example 12b.2)
Affinity DataEC50:  4.00E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633318(US20190276450, Example 12b.3)
Affinity DataEC50:  6.80E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633319(US20190276450, Example 12b.4)
Affinity DataEC50:  4.00E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633321(US20190276450, Example 14)
Affinity DataEC50:  1.11E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633324(US20190276450, Example 14.4)
Affinity DataEC50:  6.30E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633325(US20190276450, Example 14.5)
Affinity DataEC50:  7.10E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633326(US20190276450, Example 14.6)
Affinity DataEC50:  4.90E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633327(US20190276450, Example 15)
Affinity DataEC50:  7.30E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633332(US20190276450, Example 17)
Affinity DataEC50:  2.70E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633335(US20190276450, Example 17.2)
Affinity DataEC50:  3.50E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633337(US20190276450, Example 17.4)
Affinity DataEC50:  2.00E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633338(US20190276450, Example 17.5)
Affinity DataEC50:  3.20E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM633342(US20190276450, Example 20)
Affinity DataEC50:  4.50E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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