Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S'
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  4.60nMAssay Description:Binding affinity for rat L-type [Ca2+] channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50283421(((E)-Azacyclotridec-1-en-2-yl)-(2,2-diphenyl-penty...)
Affinity DataEC50:  61nMAssay Description:Binding of [3H]nitrendipine to calcium channel in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 79nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 398nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50101095(CHEMBL3325957)
Affinity DataKi:  480nMAssay Description:Inhibition of rat brain cortex L-type Ca2+-channel phenylalkylamine siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 481nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50280989(2,6-dimethyl-5-methyloxycarbonyl-4-(3-nitrophenyl)...)
Affinity DataIC50: 592nMAssay Description:Inhibition of [3H]PN-200-110 binding to L-type calcium channels in rat cortex membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50101095(CHEMBL3325957)
Affinity DataKi:  800nMAssay Description:Inhibition of rat brain cortex L-type Ca2+-channel benzothiazepine siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50080302(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50: 900nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to rat L-type Ca-channel receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50080296(PD-32577 | 2-(1-azepanylmethyl)-4-{1-[3-(1-azepany...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085561(4-[2-(3-{2-[2-(3-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50080295(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085560(4-[2-(3-{2-[2-(4-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50231569(Cilansetron | KC-9946)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of [3H]D-888 binding to L-type calcium channel verapamil site of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50212319(CHEMBL18412)
Affinity DataIC50: 5.87E+3nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2018
Entry Details

LigandPNGBDBM50080299(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50231569(Cilansetron | KC-9946)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50019968(CHEMBL143865 | 7-Ethyl-1,3,5-trimethyl-6,7-dihydro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]nitrendipine from L-type [Ca2+] channel of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM85330(NSC_68647 | CAS_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]D-888 binding to L-type calcium channel verapamil site of rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50101095(CHEMBL3325957)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of rat whole brain L-type Ca2+-channel dihydropyridine siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
LigandPNGBDBM50001689(4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy...)
Affinity DataIC50: 5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50230150(CHEMBL345052)
Affinity DataIC50: 5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50230151(CHEMBL136313)
Affinity DataIC50: 5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details Article
PubMed