Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)'
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.680nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14773(Ariflo | 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyph...)
Affinity DataIC50: 11nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14797(ethyl 1-(2-chlorophenyl)-3,5-dimethyl-1H-pyrazole-...)
Affinity DataIC50: 19nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14798(ethyl 3,5-dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4...)
Affinity DataIC50: 21nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14796(ethyl 1-(4-aminophenyl)-3,5-dimethyl-1H-pyrazole-4...)
Affinity DataIC50: 160nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14785(ethyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxyl...)
Affinity DataIC50: 270nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14769(6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...)
Affinity DataIC50: 390nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14786(ethyl 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-ca...)
Affinity DataIC50: 880nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14795(ethyl 3,5-dimethyl-1-(4-nitrophenyl)-1H-pyrazole-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 1.10E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14772(5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazoli...)
Affinity DataIC50: 1.10E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14794(ethyl 1-(4-methoxyphenyl)-3,5-dimethyl-1H-pyrazole...)
Affinity DataIC50: 2.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14776(CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...)
Affinity DataIC50: 3.90E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14790(ethyl 1-(2,4-dinitrophenyl)-3,5-dimethyl-1H-pyrazo...)
Affinity DataIC50: 4.60E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14793(ethyl 3,5-dimethyl-1-(4-sulfamoylphenyl)-1H-pyrazo...)
Affinity DataIC50: 9.10E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 1.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14792(ethyl 1-(4-tert-butylphenyl)-3,5-dimethyl-1H-pyraz...)
Affinity DataIC50: 1.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14784(ethyl 3-amino-5-(4-methoxyphenyl)-1H-pyrazole-4-ca...)
Affinity DataIC50: 1.90E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 1.90E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14787(ethyl 3,5-dimethyl-1-(quinolin-8-yl)-1H-pyrazole-4...)
Affinity DataIC50: 1.90E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14791(ethyl 3,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]-...)
Affinity DataIC50: 2.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14788(ethyl 5-amino-1-{8-thia-4,6-diazatricyclo[7.4.0.0^...)
Affinity DataIC50: 5.00E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14779(ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate | Pyr...)
Affinity DataIC50: 8.20E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14789(ethyl 1-[3,5-bis(trifluoromethyl)phenyl]-3,5-dimet...)
Affinity DataIC50: 9.70E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14780(ethyl 3-methyl-1H-pyrazole-4-carboxylate | Pyrazol...)
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14778(3,5-dimethyl-1H-pyrazole-4-carboxylic acid | Pyraz...)
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14783(methyl 3-methyl-5-(5-methyl-1,2-oxazol-3-yl)-1H-py...)
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14782(5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ...)
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed
LigandPNGBDBM14781(ethyl 3-amino-1H-pyrazole-4-carboxylate | Pyrazole...)
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2007
Entry Details Article
PubMed