Compile Data Set for Download or QSAR
Report error Found 208 Enz. Inhib. hit(s) with all data for entry = 50037053
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition Protein kinase C (PKC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117342BDBM50117342(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117334BDBM50117334(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117354BDBM50117354(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Extracellular signal-regulated kinase 2 (Erk2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117330BDBM50117330(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117348BDBM50117348(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117337BDBM50117337(4-[7-(2-Methoxy-ethoxy)-quinazolin-4-yl]-piperazin...)
Affinity DataIC50: 2nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117335BDBM50117335(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117326BDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117312BDBM50117312(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 4nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117312BDBM50117312(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117314BDBM50117314(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117311BDBM50117311(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117326BDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 6nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117378BDBM50117378(4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Affinity DataIC50: 9nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117323BDBM50117323(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117316BDBM50117316(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117314BDBM50117314(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 16nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117356BDBM50117356(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 20nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117319BDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 20nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117311BDBM50117311(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 21nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117312BDBM50117312(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 22nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13535BDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataIC50: 26nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117322BDBM50117322(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 26nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117326BDBM50117326(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 29nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117328BDBM50117328(4-{7-[3-(3,3-Difluoro-piperidin-1-yl)-propoxy]-6-m...)
Affinity DataIC50: 29nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117354BDBM50117354(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 32nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117314BDBM50117314(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 35nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13535BDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataIC50: 36nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117381BDBM50117381(4-{6-Methoxy-7-[3-(2-methyl-propane-1-sulfonyl)-pr...)
Affinity DataIC50: 36nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117311BDBM50117311(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 39nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117360BDBM50117360(4-[7-(2-Methoxy-ethoxy)-quinazolin-4-yl]-piperazin...)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117352BDBM50117352(4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117377BDBM50117377(4-{7-[3-(4,4-Difluoro-piperidin-1-yl)-propoxy]-6-m...)
Affinity DataIC50: 40nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117319BDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 40nMAssay Description:Inhibition of chimeric PDGF receptor with FLT-3 cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117304BDBM50117304(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Affinity DataIC50: 50nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117380BDBM50117380(4-{6-Methoxy-7-[3-(3-methyl-butane-1-sulfonyl)-pro...)
Affinity DataIC50: 50nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117311BDBM50117311(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 51nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117333BDBM50117333(4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazol...)
Affinity DataIC50: 53nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117333BDBM50117333(4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazol...)
Affinity DataIC50: 60nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117319BDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 60nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117319BDBM50117319(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Affinity DataIC50: 60nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117368BDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 70nMAssay Description:Inhibition of chimeric PDGF receptor with FLT-3 cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117312BDBM50117312(4-{6-Methoxy-7-[3-(4-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 73nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117314BDBM50117314(4-{6-Methoxy-7-[3-(2-methyl-piperidin-1-yl)-propox...)
Affinity DataIC50: 74nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50117362BDBM50117362(4-[7-(3-Dimethylamino-propoxy)-6-methoxy-quinazoli...)
Affinity DataIC50: 76nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
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