Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50015100
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151362(4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151353(4-(4-Fluoro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyri...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151362(4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.020-0.026)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.020-0.026)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151362(4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.019-0.032)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151353(4-(4-Fluoro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  30nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151354(5-(8-Methyl-[1,5]naphthyridin-2-yl)-4-pyridin-2-yl...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.021-0.042)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyri...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.029-0.032)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.038-0.042)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151353(4-(4-Fluoro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.040-0.044)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyri...)
Affinity DataIC50:  50nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50:  120nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151354(5-(8-Methyl-[1,5]naphthyridin-2-yl)-4-pyridin-2-yl...)
Affinity DataIC50:  220nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151352(5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...)
Affinity DataIC50:  260nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151352(5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...)
Affinity DataIC50:  380nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.180-0.790)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151348(4-(pyridin-2-yl)-5-(quinolin-4-yl)thiazol-2-amine ...)
Affinity DataIC50:  420nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151348(4-(pyridin-2-yl)-5-(quinolin-4-yl)thiazol-2-amine ...)
Affinity DataIC50:  720nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.095-5.521)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151350(4-(4-Chloro-pyridin-2-yl)-5-quinolin-4-yl-thiazol-...)
Affinity DataIC50:  1.02E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.289-3.621)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151351(5''-Quinolin-4-yl-[2,4'']bithiazolyl-2''-ylamine |...)
Affinity DataIC50:  1.17E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.783-1.764)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151356(4-(2-Fluoro-phenyl)-5-quinolin-4-yl-thiazol-2-ylam...)
Affinity DataIC50:  1.25E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.356-4.455)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151349(4-(5-Chloro-pyridin-2-yl)-5-quinolin-4-yl-thiazol-...)
Affinity DataIC50:  1.77E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.864-3.661)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151358(4-Pyridin-2-yl-5-quinolin-2-yl-thiazol-2-ylamine |...)
Affinity DataIC50:  3.54E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (1.375-9.154)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151364(4-(pyridin-3-yl)-5-(quinolin-4-yl)thiazol-2-amine ...)
Affinity DataIC50:  3.98E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (2.423-6.540)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151351(5''-Quinolin-4-yl-[2,4'']bithiazolyl-2''-ylamine |...)
Affinity DataIC50:  6.58E+3nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151356(4-(2-Fluoro-phenyl)-5-quinolin-4-yl-thiazol-2-ylam...)
Affinity DataIC50:  6.67E+3nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151355(5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-...)
Affinity DataIC50:  7.94E+3nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (3.221-19.588)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151365(5-(6-Ethoxy-[1,5]naphthyridin-2-yl)-4-pyridin-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151364(4-(pyridin-3-yl)-5-(quinolin-4-yl)thiazol-2-amine ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151350(4-(4-Chloro-pyridin-2-yl)-5-quinolin-4-yl-thiazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151349(4-(5-Chloro-pyridin-2-yl)-5-quinolin-4-yl-thiazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151358(4-Pyridin-2-yl-5-quinolin-2-yl-thiazol-2-ylamine |...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151361(5-(naphthalen-1-yl)-4-(pyridin-2-yl)thiazol-2-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151359(4-(5-Methyl-pyridin-2-yl)-5-quinolin-4-yl-thiazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity for Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151360(4-(2-Methoxy-phenyl)-5-quinolin-4-yl-thiazol-2-yla...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151360(4-(2-Methoxy-phenyl)-5-quinolin-4-yl-thiazol-2-yla...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity for Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151359(4-(5-Methyl-pyridin-2-yl)-5-quinolin-4-yl-thiazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151365(5-(6-Ethoxy-[1,5]naphthyridin-2-yl)-4-pyridin-2-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity for Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151355(5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151361(5-(naphthalen-1-yl)-4-(pyridin-2-yl)thiazol-2-amin...)
Affinity DataIC50:  1.10E+4nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (5.326-22.574)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of MSK-1 kinase binding in fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase B-raf(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of Protein kinase Raf-B binding in fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase binding in HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ITK/TSK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of IL-2-inducible T-cell kinase binding in HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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