Compile Data Set for Download or QSAR
Report error Found 111 Enz. Inhib. hit(s) with all data for entry = 50032704
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333433(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)az...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333434(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)az...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333448(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)py...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333442(4-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)pi...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333447(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)py...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333436(3-(2-(2,6-dichlorophenoxy)-6-fluorophenoxy)azetidi...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333441(4-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)pi...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333445(3-(2-fluoro-6-(2-fluorophenoxy)phenoxy)pyrrolidine...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309519(2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333431(3-(2-fluoro-6-(2-fluorophenoxy)phenoxy)azetidine |...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333449((S)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333432(3-(2-(2-chlorophenoxy)-6-fluorophenoxy)azetidine |...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333437(3-(2-(2-chloro-6-methylphenoxy)-6-fluorophenoxy)az...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333438(3-(2-(2,3-dichlorophenoxy)-6-fluorophenoxy)azetidi...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333446(3-(2-(2-chlorophenoxy)-6-fluorophenoxy)pyrrolidine...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333430(3-(2-(2-fluorophenoxy)phenoxy)azetidine | CHEMBL16...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333433(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)az...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333440(4-(2-fluoro-6-(2-fluorophenoxy)phenoxy)piperidine ...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50309519(2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333429(3-(2-phenoxyphenoxy)azetidine | CHEMBL1645596)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333452(3-(azetidin-3-yloxy)-2-(2-chloro-6-fluorophenoxy)p...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333452(3-(azetidin-3-yloxy)-2-(2-chloro-6-fluorophenoxy)p...)
Affinity DataKi:  73nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataEC50:  77nMAssay Description:Agonist activity at 5HT1A receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333443(3-(2-fluoro-6-(2-fluorophenoxy)phenoxy)piperidine ...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333438(3-(2-(2,3-dichlorophenoxy)-6-fluorophenoxy)azetidi...)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]citalopram from human SERT by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333448(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)py...)
Affinity DataEC50:  97nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333434(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)az...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333433(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)az...)
Affinity DataKi:  138nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333436(3-(2-(2,6-dichlorophenoxy)-6-fluorophenoxy)azetidi...)
Affinity DataKi:  164nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333446(3-(2-(2-chlorophenoxy)-6-fluorophenoxy)pyrrolidine...)
Affinity DataKi:  192nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333444(3-(2-(2-fluorophenoxy)phenoxy)pyrrolidine | CHEMBL...)
Affinity DataKi:  193nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309519(2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...)
Affinity DataKi:  194nMAssay Description:Displacement of [3H]citalopram from human SERT by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333433(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)az...)
Affinity DataEC50:  197nMAssay Description:Agonist activity at 5HT1A receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333432(3-(2-(2-chlorophenoxy)-6-fluorophenoxy)azetidine |...)
Affinity DataKi:  198nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333451(2-(2-chloro-6-fluorophenoxy)-3-(pyrrolidin-3-yloxy...)
Affinity DataKi:  203nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333441(4-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)pi...)
Affinity DataKi:  218nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333434(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)az...)
Affinity DataEC50:  225nMAssay Description:Agonist activity at 5HT1A receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333448(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)py...)
Affinity DataKi:  226nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333434(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)az...)
Affinity DataEC50:  239nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  278nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333438(3-(2-(2,3-dichlorophenoxy)-6-fluorophenoxy)azetidi...)
Affinity DataKi:  312nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333442(4-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)pi...)
Affinity DataKi:  323nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333447(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)py...)
Affinity DataKi:  328nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  341nMAssay Description:Agonist activity at 5HT1A receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
LigandPNGBDBM50333438(3-(2-(2,3-dichlorophenoxy)-6-fluorophenoxy)azetidi...)
Affinity DataKi:  374nMAssay Description:Displacement of [3H]nisoxetine from human NET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
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