Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50022526
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human CHK1 by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CHK1 in etoposide-induced human HT-29 cells assessed as G2 checkpoint abrogation in presence of nocodazole by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 63nMAssay Description:Inhibition of CHK1 in etoposide-induced human MIA PaCa-2 cells assessed as G2 checkpoint abrogation in presence of nocodazole by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 84nMAssay Description:Inhibition of CHK1 in etoposide-induced human Calu-6 cells assessed as G2 checkpoint abrogation in presence of nocodazole by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 15(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human ERK8 in presence of ATP by by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 220nMAssay Description:Inhibition of CHK1 in etoposide-induced human SW620 cells assessed as G2 checkpoint abrogation in presence of nocodazole by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase D1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 298nMAssay Description:Inhibition of PRKD1 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 361nMAssay Description:Inhibition of human RSK2 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 362nMAssay Description:Inhibition of human RSK1 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 582nMAssay Description:Inhibition of FLT3 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP/microtubule affinity-regulating kinase 3(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 698nMAssay Description:Inhibition of human MARK3 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 711nMAssay Description:Inhibition of human NUAK1 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human CHK2 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of human CLK2 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase BRSK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of human BRSK1 by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of human CHK2 by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of AMPK alpha1/beta1/gamma1 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 3.47E+3nMAssay Description:Inhibition of PHKG1 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 9.03E+3nMAssay Description:Inhibition of CDK1/CyclB (unknown origin) in presence of ATP by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM328993(US9663503, Compound 1 | 5-[[4-[[(2R)-morpholin-2-y...)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of VEGFR1 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed