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Found 21 Enz. Inhib. hit(s) with all data for entry = 50000246
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  750nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced current response by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50140144(CHEMBL2387060)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of TRPA1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50140156(CHEMBL2387062)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of TRPA1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243347(CHEMBL4064244)
Affinity DataIC50:  1.61E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243348(CHEMBL3827411)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | 5-(4-hydroxyphenethyl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243349(CHEMBL4090371)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243350(CHEMBL4088443)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50140144(CHEMBL2387060)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50045922(5-[2-(3-Hydroxy-phenyl)-vinyl]-benzene-1,3-diol | ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM23929(1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benz...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243347(CHEMBL4064244)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50140144(CHEMBL2387060)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50045922(5-[2-(3-Hydroxy-phenyl)-vinyl]-benzene-1,3-diol | ...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM23929(1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benz...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243350(CHEMBL4088443)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243348(CHEMBL3827411)
Affinity DataEC50: >3.00E+4nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50243349(CHEMBL4090371)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hyogo University Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | 5-(4-hydroxyphenethyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed