Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50012937
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 35nMAssay Description:Inhibition of URAT1 (unknown origin) transfected in dog MDCK cells assessed as inhibition of [14C]uric acid uptake by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561689(Dotinurad | Fyu-981)
Affinity DataIC50: 37nMAssay Description:Inhibition of human URAT1 expressed in Xenopus laevis oocytes assessed as inhibition of [14C]uric acid uptake measured after 60 mins by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human URAT1 expressed in Xenopus laevis oocytes assessed as inhibition of [14C]uric acid uptake measured after 60 mins by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 200nMAssay Description:Inhibition of URAT1 (unknown origin) transfected in dog MDCK cells assessed as inhibition of [14C]uric acid uptake by liquid scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561676(CHEMBL4762461)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561694(CHEMBL4748804)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561692(CHEMBL4749075)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561698(CHEMBL4792097)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561678(CHEMBL4796932)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561696(CHEMBL4760971)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561689(Dotinurad | Fyu-981)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561693(CHEMBL4756915)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561682(CHEMBL4796568)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561675(CHEMBL4781629)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561687(CHEMBL4744184)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561683(CHEMBL4744854)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561697(CHEMBL4762003)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561685(CHEMBL4740995)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561681(CHEMBL4753182)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561695(CHEMBL4778323)
Affinity DataIC50: 3.39E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561685(CHEMBL4740995)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561690(CHEMBL4781818)
Affinity DataIC50: 8.33E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561679(CHEMBL4757464)
Affinity DataIC50: 8.39E+4nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561691(CHEMBL4790389)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561677(CHEMBL4782683)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561680(CHEMBL4785752)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561684(CHEMBL4800504)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561686(CHEMBL4756625)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
Fuji Yakuhin

Curated by ChEMBL
LigandPNGBDBM50561688(CHEMBL4785815)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed