Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50017842
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataKi:  9nMAssay Description:Inhibition of rat ATX by Michaelis-Menten analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50501623(CHEMBL4062929)
Affinity DataIC50: 20nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataKi:  24nMAssay Description:Inhibition of rat ATX by Michaelis-Menten analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataIC50: 29nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 18:1 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataIC50: 32nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 20:0 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataIC50: 33nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 20:0 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataIC50: 34nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 16:0 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataIC50: 45nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 18:1 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605401(CHEMBL5181584)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataIC50: 54nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 14:0 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataEC50:  60nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as AKT phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataEC50:  60nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as ERK phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605407(CHEMBL5205292)
Affinity DataIC50: 60nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605400(CHEMBL5202425)
Affinity DataIC50: 70nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605399(CHEMBL5198478)
Affinity DataIC50: 70nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataIC50: 72nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 16:0 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605402(CHEMBL5185387)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataIC50: 84nMAssay Description:Inhibition of rat ATX lysoPLD activity assessed as reduction in choline release using 14:0 LPC as substrate measured after 60 mins by HVA fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataEC50:  100nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as AKT phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataEC50:  100nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as ERK phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 131nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605398(CHEMBL5175407)
Affinity DataIC50: 150nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataEC50:  186nMAssay Description:Inhibition of LPA-mediated ATX activation in human MDA-MB-231 cells assessed as reduction in cell migration incubated for 4 hrs in using18:1 LPC as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605404(CHEMBL5201145)
Affinity DataIC50: 200nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605403(CHEMBL5182158)
Affinity DataIC50: 210nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605394(CHEMBL5187829)
Affinity DataIC50: 400nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605396(CHEMBL5177229)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187693(CHEMBL3186509)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605393(CHEMBL5187548)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605392(CHEMBL5178081)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605395(CHEMBL5183461)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50605397(CHEMBL5187146)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of rat ATX lysoPLD activity using LPC as substrate assessed as reduction in choline release measured after 60 mins by HVA fluorescence bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed