Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50021499
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50155926BDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of canonical NLRP3 in human MDMsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50155926BDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of noncanonical NLRP3 in human MDMsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 695525BDBM695525(US12084416, Example 56)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in LPS/ATP induced IL-1beta production preincubated with LPS for 4 hrs prior to compou...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50636753BDBM50636753(Emlenoflast | Inzomelid | Izd-174 | Izd174 | MCC-7...)
Affinity DataIC50: 16nMAssay Description:Inhibition of NLRP3 in mouse BMDMs assessed as reduction in LPS/ATP-induced IL-1beta release preincubated for 30 mins in presence of LPS followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50607509BDBM50607509(CHEMBL5219789)
Affinity DataIC50: 51nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in caspase-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50607509BDBM50607509(CHEMBL5219789)
Affinity DataIC50: 63nMAssay Description:Inhibition of NLRP3 in human BMDM cells assessed as reduction in caspase-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641304BDBM50641304(CHEMBL5563663)
Affinity DataIC50: 130nMAssay Description:Inhibition of NLRP3 inflammasome in mouse BMDMs assessed as reduction in pyroptosis activity preincubated with LPS for 4 hrs followed by compound add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641301BDBM50641301(CHEMBL5574510)
Affinity DataIC50: 183nMAssay Description:Covalent inhibition of NLRP3 in mouse BMDMs assessed as reduction in LPS/nigericin induced IL-1beta secretion pretreated with LPS for 3 hrs followed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641304BDBM50641304(CHEMBL5563663)
Affinity DataIC50: 190nMAssay Description:Inhibition of NLRP3 inflammasome in mouse BMDMs assessed as reduction in IL-1beta activity preincubated with LPS for 4 hrs followed by compound addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641300BDBM50641300(CHEMBL5572607)
Affinity DataIC50: 920nMAssay Description:Inhibition of NLRP3 in LPS/ATP induced mouse J774.A1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505850BDBM50505850(Dapansutrile | OLT-1177 | OLT1177)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NLRP3 inflammasome in human MDM cells assessed as reduction in LPS/nigericin induced IL-1beta secretion preincubated with LPS for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641303BDBM50641303(CHEMBL5574557)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse BMDMs assessed as reduction in IL-1beta activity preincubated with LPS for 4 hrs followed by compound addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50372524BDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of NLRP3 in LPS/ATP induced mouse J774.A1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641299BDBM50641299(CHEMBL5569557)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of NLRP3 in LPS/ATP induced mouse J774.A1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641303BDBM50641303(CHEMBL5574557)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse BMDMs assessed as reduction in pyroptosis activity preincubated with LPS for 4 hrs followed by compound add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641302BDBM50641302(CHEMBL5590859)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of NLRP3 in mouse J774.A1 cells assessed as reduction in LPS/ATP induced IL-1beta secretionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641307BDBM50641307(CHEMBL5592680)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced LDH level preincubated with LPS for 4 hrs follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641306BDBM50641306(CHEMBL5566199)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced LDH level preincubated with LPS for 4 hrs follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641305BDBM50641305(CHEMBL5575846)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced LDH level preincubated with LPS for 4 hrs follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641308BDBM50641308(CHEMBL5568678)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced IL-1beta level preincubated with LPS for 4 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641308BDBM50641308(CHEMBL5568678)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced LDH level preincubated with LPS for 4 hrs follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641307BDBM50641307(CHEMBL5592680)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced IL-1beta level preincubated with LPS for 4 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641306BDBM50641306(CHEMBL5566199)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced IL-1beta level preincubated with LPS for 4 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641305BDBM50641305(CHEMBL5575846)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as decrease in LPS/nigericin induced IL-1beta level preincubated with LPS for 4 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505856BDBM50505856(CHEMBL3188223)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction in LPS/ATP stimulated IL-1beta release preincubated with LPS for 4 hrs followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605174BDBM50605174(CHEMBL1164920)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of NLRP3 in LPS/ATP induced human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505851BDBM50505851(CHEMBL4583133)
Affinity DataIC50: 8.45E+3nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction in LPS/ATP stimulated IL-1beta release preincubated with LPS for 4.5 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012957BDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRP3 in human BMDMs assessed as reduction in LPS/ATP induced IL-1beta secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed