Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50021506
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50641349(CHEMBL5571945)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate incubated for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM50641349(CHEMBL5571945)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of HDAC6 (unknown origin) using expressed in Sf9 cells using Boc-Lys(acetyI)-AMC as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant HDAC3 in HeLa cells using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as fluorogenic substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 4(Human)TBA
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of HDAC4 (unknown origin) using biotinylated histone H3 KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 15 mins by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 25nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant HDAC2 in HeLa cells using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as fluorogenic substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50587652(CHEMBL5198491)
Affinity DataIC50: 30nMAssay Description:Inhibition of BRD4 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50587652(CHEMBL5198491)
Affinity DataIC50: 31nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 34nMAssay Description:Inhibition of HDAC6 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 38nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) incubated for 180 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 39nMAssay Description:Inhibition of HDAC3 (unknown origin) using biotinylated histone H3 KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 52nMAssay Description:Inhibition of HDAC2 (unknown origin) by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 72nMAssay Description:Inhibition of HDAC6 (unknown origin) using biotinylated histone H3 KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 78nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) incubated for 180 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 5(Human)TBA
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 107nMAssay Description:Inhibition of HDAC5 (unknown origin) using biotinylated histone H3 KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 133nMAssay Description:Inhibition of recombinant BRD3 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 181nMAssay Description:Inhibition of human recombinant HDAC1 in HeLa cells using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as fluorogenic substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 192nMAssay Description:Inhibition of HDAC8 (unknown origin) using Fluoro-Substrate Peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 291nMAssay Description:Inhibition of human recombinant HDAC in HeLa cells using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as fluorogenic substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 316nMAssay Description:Inhibition of recombinant BRD2 BD1 (unknown origin) incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetREST corepressor 1(Human)TBA
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 330nMAssay Description:Inhibition of N-terminal GST-tagged LSD1 (171 to 852 residues) (unknown origin) expressed in Escherichia coli FLAG-tagged CoREST1 (unknown origin) tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50113851(Tranylcypromine,(+) | TRANYLCYPROMINE | US8609708,...)
Affinity DataIC50: 870nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50641350(CHEMBL5575739)
Affinity DataIC50: 930nMAssay Description:Inhibition of DNMT3A/DNMT3L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant HDAC6 in HeLa cells using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as fluorogenic substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50113851(Tranylcypromine,(+) | TRANYLCYPROMINE | US8609708,...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50641350(CHEMBL5575739)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of DNMT3B/3L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50641350(CHEMBL5575739)
Affinity DataIC50: 2.02E+3nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50113851(Tranylcypromine,(+) | TRANYLCYPROMINE | US8609708,...)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM50641350(CHEMBL5575739)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using ArgHisLysLys(Ac) as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569835(CHEMBL4850917)
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50569836(CHEMBL4850926)
Affinity DataIC50: 3.22E+4nMAssay Description:Inhibition of BRDT BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM50641350(CHEMBL5575739)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed