Compile Data Set for Download or QSAR
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Found 32 Enz. Inhib. hit(s) with all data for entry = 50036607
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064195((2S,6R,11S)-6,11-Dimethyl-3-(2-phenylamino-ethyl)-...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064191((2S,6R,11S)-6,11-Dimethyl-3-(2-pyrrolidin-1-yl-eth...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064188((2S,6R,11S)-6,11-Dimethyl-3-(2-morpholin-4-yl-ethy...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064190((2S,6R,11S)-3-(2-Diethylamino-ethyl)-6,11-dimethyl...)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064187((2S,6R,11S)-3-(2-Azepan-1-yl-ethyl)-6,11-dimethyl-...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064189((2S,6R,11S)-3-(2-Dimethylamino-ethyl)-6,11-dimethy...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064197((2S,6R,11S)-3-(2-Benzylamino-ethyl)-6,11-dimethyl-...)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064194((2S,6R,11S)-3-(2-Cyclohexylamino-ethyl)-6,11-dimet...)
Affinity DataKi:  42nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064192((2S,6R,11S)-3-[2-(Ethyl-phenyl-amino)-ethyl]-6,11-...)
Affinity DataKi:  42nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50368882(CHEMBL147585 | SK&F-10047 | SK-10047)
Affinity DataKi:  169nMAssay Description:Inhibition of [3H]pentazocine binding to sigma-1 sites in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  238nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064188((2S,6R,11S)-6,11-Dimethyl-3-(2-morpholin-4-yl-ethy...)
Affinity DataKi:  419nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064187((2S,6R,11S)-3-(2-Azepan-1-yl-ethyl)-6,11-dimethyl-...)
Affinity DataKi:  1.84E+3nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064191((2S,6R,11S)-6,11-Dimethyl-3-(2-pyrrolidin-1-yl-eth...)
Affinity DataKi:  1.95E+3nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064190((2S,6R,11S)-3-(2-Diethylamino-ethyl)-6,11-dimethyl...)
Affinity DataKi:  1.99E+3nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi:  7.80E+3nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064191((2S,6R,11S)-6,11-Dimethyl-3-(2-pyrrolidin-1-yl-eth...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064193((2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards Dopamine receptor D2 in the rat striatal membranes using [3H]spiroperidolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50368882(CHEMBL147585 | SK&F-10047 | SK-10047)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50368882(CHEMBL147585 | SK&F-10047 | SK-10047)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064190((2S,6R,11S)-3-(2-Diethylamino-ethyl)-6,11-dimethyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064188((2S,6R,11S)-6,11-Dimethyl-3-(2-morpholin-4-yl-ethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064194((2S,6R,11S)-3-(2-Cyclohexylamino-ethyl)-6,11-dimet...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064189((2S,6R,11S)-3-(2-Dimethylamino-ethyl)-6,11-dimethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064189((2S,6R,11S)-3-(2-Dimethylamino-ethyl)-6,11-dimethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064194((2S,6R,11S)-3-(2-Cyclohexylamino-ethyl)-6,11-dimet...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50064187((2S,6R,11S)-3-(2-Azepan-1-yl-ethyl)-6,11-dimethyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]spiroperidol binding to Dopamine receptor D2 of rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed