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Target
Anoctamin-1
Ligand
BDBM509569
Substrate
n/a
Meas. Tech.
Automated Whole-Cell Patch Clamp Assay to Detect TMEM16A Activity in Recombinant Cells
EC50
460±n/a nM
Citation
 Collingwood, S; Mccarthy, C; Hargrave, JD; Hay, DA; Schofield, TB; Ellam, S; Buxton, C; Habgood, M; Ingram, P; Ma, CY; Napier, S; Shaikh, A; Smith, M; Stimson, C; Walker, E COMPOUNDS US Patent  US20200361871 Publication Date 11/19/2020 
Target
Name:
Anoctamin-1
Synonyms:
Discovered on gastrointestinal stromal tumors protein 1 | Oral cancer overexpressed protein 2 | Transmembrane protein 16A | Tumor-amplified and overexpressed sequence 2 | ANO1_HUMAN | ANO1 | DOG1 | ORAOV2 | TAOS2 | TMEM16A
Type:
PROTEIN
Mol. Mass.:
114103.63
Organism:
Human
Description:
ChEMBL_828184
Residue:
986
Sequence:
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL
  
Inhibitor
Name:
BDBM509569
Synonyms:
US20200361871A1, Example 2.13 | US11364246, Example 2.13
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCC(C)(C)NC(=O)c1cccc(NC(=O)Cc2ccc(F)cc2O)c1
Structure:
Search PDB for entries with ligand similarity: