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Target
Cathepsin K
Ligand
BDBM448319
Substrate
n/a
Meas. Tech.
FRET-based enzymatic assay
IC50
0.56±n/a nM
Citation
 Ma, C; Xia, Z; Sacco, MD; Hu, Y; Townsend, JA; Meng, X; Choza, J; Tan, H; Jang, J; Gongora, MV; Zhang, X; Zhang, F; Xiang, Y; Marty, MT; Chen, Y; Wang, J Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity. J Am Chem Soc 143:20697-20709 (2021) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
Cathepsin O | Cathepsin O2 | Cathepsin X | CTSO | CTSO2 | CATK_HUMAN | CTSK
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Human
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM448319
Synonyms:
GC376 | GC-376 | US20250188102, Compound GC-376
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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