Target
Tyrosine-protein kinase JAK1 [861-1152]
Ligand
BDBM173980
Substrate
n/a
Meas. Tech.
JAK1 Kinase Assay
IC50
139±n/a nM
Citation
 Brasca, MGBindi, SCaldarelli, MNesi, MOrrenius, SCPanzeri, A Substituted pyrroles active as kinases inhibitors US Patent  US9688661 Publication Date 6/27/2017 
Target
Name:
Tyrosine-protein kinase JAK1 [861-1152]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)
Type:
Protein
Mol. Mass.:
33439.94
Organism:
Homo sapiens (Human)
Description:
Human JAK1 variant (861-1152 aa)
Residue:
292
Sequence:
PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
  
Inhibitor
Name:
BDBM173980
Synonyms:
US9688661, 5-(6-Aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1H-pyrrole-3-carboxamide (compd 189)
Type:
Small organic molecule
Emp. Form.:
C16H15ClN6O
Mol. Mass.:
342.783
SMILES:
Cc1ccc(Cl)cc1-c1nc(-c2cc(N)ncn2)n(C)c1C(N)=O
Structure:
Search PDB for entries with ligand similarity: