Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [364-436]
Ligand
BDBM205429
Substrate
n/a
Meas. Tech.
Plate-Based Time-Resolved Fluorescence Energy Transfer (TR-FRET) Assays
IC50
52.0±n/a nM
Citation
 Zhou, J; Brasier, AR; Tian, B; Liu, Z; Chen, H; Rytting, E Inhibitors of bromodomain-containing protein 4 (BRD4) US Patent  US11117865B2 Publication Date 9/14/2021 
Target
Name:
Bromodomain-containing protein 2 [364-436]
Synonyms:
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | Bromodomain-containing protein 2 (BRD2)(BD2) | BRD2_HUMAN | BRD2 | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
8615.14
Organism:
Human
Description:
BD2 (364-436 aa) of P25440
Residue:
73
Sequence:
KHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVV
  
Inhibitor
Name:
BDBM205429
Synonyms:
(R)-JQ1 (3) | US9320741, (R)-JQ1 | US10407441, Compound (R)-JQ1 | US10925881, Name (R)-JQ1 | US11117865, Compound JQ1 | US11028051, Cmpd (+)-JQ1 | US11406645, Compound JQ1 | US11306105, Compound JQ1 | US11542273, Example (+)-JQ1 | US11890288, Compound (+)-JQ1
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
456.14
SMILES:
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2
Structure:
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