Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 6
Ligand
BDBM525562
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
IC50
0.200±n/a nM
Citation
 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J Heterocyclic compounds as kinase inhibitors US Patent  US11174252 Publication Date 11/16/2021 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE | CDK6_HUMAN | CDK6 | CDKN6
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Human
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM525562
Synonyms:
US11174252, Compound 1
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F
Structure:
Search PDB for entries with ligand similarity: