Target
Cyclin-dependent kinase 6
Ligand
BDBM525755
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
IC50
1.000±n/a nM
Citation
 Pham, SMChakravarty, SKankanala, JPujala, BShete, ABhatt, BAgarwal, AKSoni, SChen, J Heterocyclic compounds as kinase inhibitors US Patent  US11174252 Publication Date 11/16/2021 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Human
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM525755
Synonyms:
US11174252, Compound 442
Type:
Small organic molecule
Emp. Form.:
C26H30F2N6O
Mol. Mass.:
480.5528
SMILES:
CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2)ncc1F
Structure:
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