Target
Cyclin-dependent kinase 4
Ligand
BDBM525809
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
IC50
2.00±n/a nM
Citation
 Pham, SMChakravarty, SKankanala, JPujala, BShete, ABhatt, BAgarwal, AKSoni, SChen, J Heterocyclic compounds as kinase inhibitors US Patent  US11174252 Publication Date 11/16/2021 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Human
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM525809
Synonyms:
US11174252, Compound 501
Type:
Small organic molecule
Emp. Form.:
C27H32F2N6O
Mol. Mass.:
494.5794
SMILES:
CCN1CCC(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3OCCN(C(C)C)c3c2)nc1
Structure:
Search PDB for entries with ligand similarity: