Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [91-163]
Ligand
BDBM50365262
Substrate
n/a
Meas. Tech.
AlphaLisa Assay
IC50
63.0±n/a nM
Citation
 Upadhayaya, RS; Kethiri, R; Madan, S; Rajaiah, SK Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof US Patent  US11279703 Publication Date 3/22/2022 
Target
Name:
Bromodomain-containing protein 2 [91-163]
Synonyms:
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1) | Bromodomain-containing protein 2 (BRD2)(BD1) | BRD2_HUMAN | BRD2 | KIAA9001 | RING3
Type:
n/a
Mol. Mass.:
8836.08
Organism:
Human
Description:
BD1 (91-163 aa) of P25440
Residue:
73
Sequence:
WKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIV
  
Inhibitor
Name:
BDBM50365262
Synonyms:
CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 | US9695172, JQ1 | JQ1 | US10124009, Compound (S)-JQ1 | US10202360, Example JQ-1 | US10308662, Compound JQ-1 | US10407441, Compound (S)-JQ1 | US10617680, Example JQ-1 | US10925881, Name (S)-JQ1 | US10881668, Compound JQ1 | US11020380, Example JQ-1 | (+)-JQ1 | US11078188, Example (+)-JQ1 | US11466034, Example (+)-JQ1 | US11279703, TABLE 6.180 | US11427593, Compound JQ1 | US20250084096, Compound A | US20250221977, Compound JQ1
Type:
Small organic molecule
Emp. Form.:
C23H25ClN4O2S
Mol. Mass.:
n/a
SMILES:
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2
Structure:
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