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Target
Vasopressin V1b receptor
Ligand
BDBM175039
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
<1.00±n/a nM
Comments
extracted
Citation
 Geneste, H; Hornberger, W; Jantos, K; Kling, A; Van Gaalen, M Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases US Patent  US9688678 Publication Date 6/27/2017 
Target
Name:
Vasopressin V1b receptor
Synonyms:
AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor
Type:
Enzyme
Mol. Mass.:
46985.01
Organism:
Homo sapiens (Human)
Description:
P47901
Residue:
424
Sequence:
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
  
Inhibitor
Name:
BDBM175039
Synonyms:
US9688678, 11 (+)-3-(2-ethoxy-5-methoxyphenyl)-1-((5-methoxypyridin-2-yl)sulfonyl)-3-(6-(1-(oxetan-3-yl)piperidin-4-yl)-2,6-diazaspiro[3.3]heptan-2-yl)-2-oxoindoline-5-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C37H44N6O7S
Mol. Mass.:
716.846
SMILES:
CCOc1ccc(OC)c(c1)C1(C2C=C(C=CC2N(C1=O)S(=O)(=O)c1ccc(OC)cn1)C#N)N1CC2(CN(C2)C2CCN(CC2)C2COC2)C1 |c:14,16|
Structure:
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