Reaction Details Report a problem with these data
Target
CYP1A
Ligand
BDBM562067
Substrate
n/a
Meas. Tech.
Inhibition of CYP Enzyme Activity In Vitro
IC50
1600±n/a nM
Citation
 Peterson, RT; Asnani, A; Liu, Y; Zheng, B; Wang, Y Tricyclic compounds as Cyp1 inhibitors US Patent  US11396516 Publication Date 7/26/2022 
Target
Name:
Cytochrome P450 1A1
Synonyms:
Cytochrome P450 1A1 (CYP1A1) | P450-P1 | P450 form 6 | P450-C | Cytochrome P450 1A | CYPIA1 | Cytochrome P450 1A1 | CP1A1_HUMAN | CYP1A1
Type:
Protein
Mol. Mass.:
58177.23
Organism:
Human
Description:
P04798
Residue:
512
Sequence:
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
  
Inhibitor
Name:
BDBM562067
Synonyms:
US11396516, Example 2
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(C)OC(=O)NCCCOc1c2ccoc2cc2oc(=O)ccc12
Structure:
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