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Target
Cytochrome P450 3A43
Ligand
BDBM562067
Substrate
n/a
Meas. Tech.
Inhibition of CYP Enzyme Activity In Vitro
IC50
9300±n/a nM
Citation
 Peterson, RT; Asnani, A; Liu, Y; Zheng, B; Wang, Y Tricyclic compounds as Cyp1 inhibitors US Patent  US11396516 Publication Date 7/26/2022 
Target
Name:
Cytochrome P450 3A43
Synonyms:
Cytochrome P450 3A43 | CP343_HUMAN | CYP3A43 | Cytochrome P450 3A
Type:
PROTEIN
Mol. Mass.:
57676.64
Organism:
Human
Description:
ChEMBL_487752
Residue:
503
Sequence:
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
  
Inhibitor
Name:
BDBM562067
Synonyms:
US11396516, Example 2
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(C)OC(=O)NCCCOc1c2ccoc2cc2oc(=O)ccc12
Structure:
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