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Target
Arginase-2, mitochondrial
Ligand
BDBM50561039
Substrate
n/a
Meas. Tech.
Biological Activity of Examples 1 to 30
IC50
2120±n/a nM
Citation
 Mlynarski, SN; Grebe, T; Kawatkar, S; Finlay, MR; Simpson, I; Wang, J; Cook, S; Wu, D Arginase inhibitors and methods of use thereof US Patent  US11420984 Publication Date 8/23/2022 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase | ARGI2_HUMAN | ARG2
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Human
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50561039
Synonyms:
CHEMBL4749355 | US11420984, Example 23
Type:
Small organic molecule
Emp. Form.:
C10H21BN2O4
Mol. Mass.:
244.10
SMILES:
CN[C@H]1CN[C@](CCCCB(O)O)(C1)C(O)=O |r|
Structure:
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