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Target
Tyrosine-protein kinase Lck
Ligand
BDBM538658
Substrate
n/a
Meas. Tech.
IC50 Kinase Assays
IC50
167±n/a nM
Citation
 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors US Patent  US11542261 Publication Date 1/3/2023 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
p56-LCK | Protein YT16 | Proto-oncogene Lck | T cell-specific protein-tyrosine kinase | 2.7.10.2 | LSK | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Leukocyte C-terminal Src kinase | LCK_HUMAN | LCK | Src/Lck kinase | Lymphocyte-specific protein tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Human
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM538658
Synonyms:
NCGC 00249373 | US11254667, Compound I-17 | US11542261, Compound I-17
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Clc1ccc2ncc(-c3cccc(NC4CCCNC4)n3)n2c1
Structure:
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