Reaction Details Report a problem with these data
Target
Myosin light chain kinase family member 4
Ligand
BDBM50515430
Substrate
n/a
Meas. Tech.
n Vitro Effect Assay
IC50
>1000±n/a nM
Citation
 Fu, C; Liu, C; Chen, Y; Tu, C; Hung, C Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase US Patent  US11608319 Publication Date 3/21/2023 
Target
Name:
Myosin light chain kinase family member 4
Synonyms:
MYLK4_HUMAN | MYLK4 | SGK085
Type:
PROTEIN
Mol. Mass.:
44505.40
Organism:
Human
Description:
ChEMBL_774289
Residue:
388
Sequence:
MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQKKKNRGSDAQDFVTK
  
Inhibitor
Name:
BDBM50515430
Synonyms:
NETARSUDIL | US11608319, Compound AR-13324
Type:
Small organic molecule
Emp. Form.:
C28H29N3O3
Mol. Mass.:
455.56
SMILES:
Cc1ccc(C(=O)OCC2=CCC(C=C2)[C@@H](CN)C(=O)Nc2ccc3cnccc3c2)c(C)c1 |r,c:13,t:9|
Structure:
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