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Target
Receptor-type tyrosine-protein kinase FLT3 (D835Y)
Ligand
BDBM621167
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
Kd
0.160±n/a nM
Citation
 HOYT, SB; THOMAS, CJ; FINOCCHIO, CJ; STARCZYNOWSKI, DT; TAWA, GJ; GRACIA MALDONADO, G; ROSEBAUM, JS MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF US Patent  US20230303563 Publication Date 9/28/2023 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [D835Y]
Synonyms:
FLT3(D835Y) | FL cytokine receptor | Receptor-type tyrosine-protein kinase FLT3 (D835Y) | STK-1 | Stem cell tyrosine kinase 1 | Tyrosine Kinase FLT3 Mutant (D835Y) | FLT3_HUMAN | FLT3 | CD135 | FLK2 | STK1
Type:
n/a
Mol. Mass.:
112937.71
Organism:
Human
Description:
P36888 D835Y
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARYIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM621167
Synonyms:
1-(4-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3-yl)- amino)pyridin-2-yl)- imidazo[1,2-a]pyridin-6- yl)-1H-pyrazol-1-yl)-2- methylpropan-2-ol | US20230303563, Compound 105
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(O)Cn1cc(cn1)-c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1 |r|
Structure:
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