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Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM179474
Substrate
n/a
Meas. Tech.
Biolayer Interferometry (BLI) Binding Assay
pH
7.4000±n/a
Kd
60±18 nM
Comments
extracted
Citation
 Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent  US9675697 Publication Date 6/13/2017 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | BRD4_HUMAN | BRD4 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Human
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM179474
Synonyms:
US9675697, Cpd. No. 25
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc6c(cc1c2c(C)noc2C)[nH]c5ccnc(c3c(C)[nH]nc3c4ccccc4)c56
Structure:
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