Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 3 [51-123]
Ligand
BDBM179474
Substrate
n/a
Meas. Tech.
FP Competitive Binding Assay (No.350)
Temperature
298.1500±n/a K
Ki
10±1.00 nM
Comments
extracted
Citation
 Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent  US9675697 Publication Date 6/13/2017 
Target
Name:
Bromodomain-containing protein 3 [51-123]
Synonyms:
Bromodomain-containing protein 3 Bromo 1 domain(BRD3 BD1) | Bromodomain-containing protein 3 (BRD3)(BD1) | BRD3_HUMAN | BRD3 | KIAA0043 | RING3L
Type:
n/a
Mol. Mass.:
8887.10
Organism:
Human
Description:
BD1 (51-123 aa) of Q15059
Residue:
73
Sequence:
WKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIV
  
Inhibitor
Name:
BDBM179474
Synonyms:
US9675697, Cpd. No. 25
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc6c(cc1c2c(C)noc2C)[nH]c5ccnc(c3c(C)[nH]nc3c4ccccc4)c56
Structure:
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