Reaction Details Report a problem with these data
Target
Mitochondrial pyruvate carrier 1/2
Ligand
BDBM50103521
Substrate
n/a
Meas. Tech.
BRET-Assay
IC50
>100000±n/a nM
Citation
 MARTINELL PEDEMONTE, M; PIZCUETA LALANZA, MP; TRAVER LOPEZ, E; GARCÍA COLLAZO, AM; PÉREZ DE LA CRUZ MORENO, MA USE OF 5-[[4-[2-[5-ACETYLPYRIDIN-2-YL]ETHOXY]BENZYL]-1,3-THIAZOLIDINE-2,4-DIONE AND ITS SALTS US Patent  US20240091210 Publication Date 3/21/2024 
Target
Name:
Mitochondrial pyruvate carrier 1/2
Synonyms:
Mitochondrial pyruvate carrier 1 and 2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Mitochondrial pyruvate carrier 1
Synonyms:
Brain protein 44-like protein
Type:
Protein
Mol. Mass.:
12355.93
Organism:
Human
Description:
Q9Y5U8
Residue:
109
Sequence:
MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDMKKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHATNEVAQLIQGGRLIKHEMTKTASA
  
Component 2
Name:
Mitochondrial pyruvate carrier 2
Synonyms:
Brain protein 44 | Mitochondrial pyruvate carrier 2 | MPC2_HUMAN | MPC2 | BRP44
Type:
PROTEIN
Mol. Mass.:
14291.32
Organism:
Human
Description:
ChEMBL_117931
Residue:
127
Sequence:
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK
  
Inhibitor
Name:
BDBM50103521
Synonyms:
CHEBI:8228 | Actos | Duetact | Pioglitazone | US10188639, Compound h-rac-pio | US11141411, Compound h-rac-pio | US20240091210, Compound Pioglitazone
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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