Reaction Details Report a problem with these data
Target
Replicase polyprotein 1a [1564-1878]
Ligand
BDBM676266
Substrate
n/a
Meas. Tech.
SPR Binding Assay
IC50
330±n/a nM
Citation
 Thatcher, GR; Shen, Z; Xiong, R; Ratia, K; Rong, L; Cooper, L COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME US Patent  US20240166598 Publication Date 5/23/2024 
Target
Name:
Replicase polyprotein 1a [1564-1878]
Synonyms:
ORF1ab polyprotein (PP1ab)(1564-1878)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35383.77
Organism:
Severe acute respiratory syndrome coronavirus (SARS-CoV)
Description:
aa 1564-1878
Residue:
315
Sequence:
SMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYK
  
Inhibitor
Name:
BDBM676266
Synonyms:
US20240166598, Compound XR8-65 | US20240166598, Compound XR8-66
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@@H](NC(=O)c1cc(NC2CNC2)ccc1C)c1cccc(c1)-c1ccc(CNC2CCOC2)s1 |r|
Structure:
Search PDB for entries with ligand similarity: