Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM642882
Substrate
n/a
Meas. Tech.
HSD2 Activity
IC50
20.0±n/a nM
Citation
 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA US Patent  US20240209019 Publication Date 6/27/2024 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-beta-hydroxysteroid dehydrogenase type 2 | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | 11-DH2 | 11-beta-HSD2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | SDR9C3 | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Human
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM642882
Synonyms:
(2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((Cyclopropanecarbonyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid | US11858959, Compound 198-2 | US20240209019, Compound 198-2
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)C1CC1 |t:29|
Structure:
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