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Target
Estrogen receptor [282-595]
Ligand
BDBM683801
Substrate
n/a
Meas. Tech.
ERα TR-FRET Test
IC50
15.6±n/a nM
Citation
 Yang, X; Zhu, C; Zhang, C; Talley, JJ; Chen, C; Bao, L; Min, X; Xu, L ESTROGEN RECEPTOR ANTAGONIST US Patent  US20240217988 Publication Date 7/4/2024 
Target
Name:
Estrogen receptor [282-595]
Synonyms:
Estrogen receptor (282-595)
Type:
Enzyme
Mol. Mass.:
35261.19
Organism:
Homo sapiens (Human)
Description:
P03372[282-595]
Residue:
314
Sequence:
SAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM683801
Synonyms:
US20240217988, Example 12 | (6S,8R)-6-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)oxy)phenyl)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydrooxazolo[5,4-f]isoquinolin-2(3H)-one
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@@H]1Cc2c(ccc3[nH]c(=O)oc23)[C@H](N1CC(F)(F)F)c1c(F)cc(OC2CN(CCCF)C2)cc1F |r|
Structure:
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