Reaction Details Report a problem with these data
Target
Estrogen receptor [282-595]
Ligand
BDBM683807
Substrate
n/a
Meas. Tech.
ERα TR-FRET Test
IC50
14.7±n/a nM
Citation
 Yang, X; Zhu, C; Zhang, C; Talley, JJ; Chen, C; Bao, L; Min, X; Xu, L ESTROGEN RECEPTOR ANTAGONIST US Patent  US20240217988 Publication Date 7/4/2024 
Target
Name:
Estrogen receptor [282-595]
Synonyms:
Estrogen receptor (282-595)
Type:
Enzyme
Mol. Mass.:
35261.19
Organism:
Homo sapiens (Human)
Description:
P03372[282-595]
Residue:
314
Sequence:
SAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM683807
Synonyms:
US20240217988, Example 32
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc(NC2CN(CCCF)C2)ccc1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1ccc1[nH]c(=O)oc21 |r|
Structure:
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