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Target
Estrogen receptor [282-595]
Ligand
BDBM300969
Substrate
n/a
Meas. Tech.
ERα TR-FRET Test
IC50
62.0±n/a nM
Citation
 Yang, X; Zhu, C; Zhang, C; Talley, JJ; Chen, C; Bao, L; Min, X; Xu, L ESTROGEN RECEPTOR ANTAGONIST US Patent  US20240217988 Publication Date 7/4/2024 
Target
Name:
Estrogen receptor [282-595]
Synonyms:
Estrogen receptor (282-595)
Type:
Enzyme
Mol. Mass.:
35261.19
Organism:
Homo sapiens (Human)
Description:
P03372[282-595]
Residue:
314
Sequence:
SAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM300969
Synonyms:
US10961241, Example 36 | BDBM300970 | US10961241, Example 17 | US10131663, Example 35 | N-(1-(3- fluoropropyl) azetidin-3-yl)-6- ((6S,8R)-6- deuterio-8- methyl-7- (2,2,2- trifluoroethyl)- 6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinolin- 6-yl)pyridin-3- amine | US10590130, Example 32 | US20240217988, Example AZD9833
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)(F)F)c1ccc(NC2CN(CCCF)C2)cn1 |r|
Structure:
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