Reaction Details Report a problem with these data
Target
cAMP-dependent protein kinase catalytic subunit PRKX
Ligand
BDBM687754
Substrate
n/a
Meas. Tech.
ROCK1, ROCK2, PRKX, and PKA Inhibition Assay
IC50
31.4±n/a nM
Citation
 Kaiser, TM AZAINDOLE ROCK INHIBITORS US Patent  US20240246972 Publication Date 7/25/2024 
Target
Name:
cAMP-dependent protein kinase catalytic subunit PRKX
Synonyms:
Serine/threonine-protein kinase PRKX | PRKX_HUMAN | PRKX | PKX1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40897.91
Organism:
Human
Description:
gi_4826948
Residue:
358
Sequence:
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
  
Inhibitor
Name:
BDBM687754
Synonyms:
US20240246972, Compound 1 | Synthesis of N-(2-fluorobenzyl)-1-methyl-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: