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Target
cAMP-dependent protein kinase catalytic subunit alpha
Ligand
BDBM687754
Substrate
n/a
Meas. Tech.
ROCK1, ROCK2, PRKX, and PKA Inhibition Assay
IC50
238±n/a nM
Citation
 Kaiser, TM AZAINDOLE ROCK INHIBITORS US Patent  US20240246972 Publication Date 7/25/2024 
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase, alpha-catalytic subunit | PKA C-alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | KAPCA_HUMAN | PRKACA | PKACA | cAMP-dependent protein kinase (PKA)
Type:
Enzyme Catalytic Subunit
Mol. Mass.:
40598.73
Organism:
Human
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM687754
Synonyms:
US20240246972, Compound 1 | Synthesis of N-(2-fluorobenzyl)-1-methyl-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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