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Target
Alpha-mannosidase 2
Ligand
BDBM50016706
Substrate
n/a
Meas. Tech.
Golgi α-Mannosidase II (alpha-hGMII) and α-Mannosidase (alpha-hLM) Activity Assay
IC50
40.0±n/a nM
Citation
 CHENG, W; CHEN, W; CHEN, Y; CHENG, T; SHEN, C; HSIEH, C; HUNG, P POLYHYDROXYLATED INDOLIZIDINE AND PYRROLIZIDINE DERIVATIVES AND USES THEREOF US Patent  US20240190866A1 Publication Date 6/13/2024 
Target
Name:
Alpha-mannosidase 2
Synonyms:
Mannosidase alpha class 2A member 1 | Lysosomal acid alpha-mannosidase | Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase | Alpha-mannosidase 2A1 | Mannosidase alpha class 2B member 1 | Golgi alpha-mannosidase II | MA2A1_HUMAN | MAN2A1 | MANA2
Type:
Protein
Mol. Mass.:
131156.65
Organism:
Human
Description:
Q16706
Residue:
1144
Sequence:
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR
  
Inhibitor
Name:
BDBM50016706
Synonyms:
CHEMBL63139 | Octahydro-indolizine-1,2,8-triol | Swainsonine | Tridolgosir | US20240190866, Compound Swainsonine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
173.11
SMILES:
[H][C@@]12[C@H](O)[C@H](O)CN1CCC[C@H]2O
Structure:
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