Reaction Details Report a problem with these data
Target
Caspase-7
Ligand
BDBM10298
Substrate
Caspase Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
170±n/a nM
Citation
 Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem 44:2015-26 (2001) [PubMed]  Article 
Target
Name:
Caspase-7
Synonyms:
Caspase | caspase 7, apoptosis-related cysteine peptidase | CMH-1 | CASP-7 | Apoptotic protease Mch-3 | CASP7_HUMAN | CASP7 | MCH3
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Human
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM10298
Synonyms:
1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione | Isatin analog 2
Type:
Small organic molecule
Emp. Form.:
C15H10N2O4
Mol. Mass.:
282.06
SMILES:
O=C1N(Cc2ccccc2)c2ccc(cc2C1=O)N(=O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase Fluorogenic Substrate
Synonyms:
Caspase Fluorogenic Substrate | Ac-DEVD-AMC
Type:
Peptide
Mol. Mass.:
1461.77
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
16
Sequence:
ACASPGLVALASPAMC