Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase FKBP5
Ligand
BDBM50088378
Substrate
n/a
Meas. Tech.
SPR Assay to Determine Binding Affinity to FK506-Binding Proteins (FKBP)
Kd
811±n/a nM
Citation
 Bonazzi, S; Connolly, M; Glass, DJ; Mihalic, M; Patterson, AW; Roggo, S; Shavlakadze, T Rapamycin derivatives US Patent  US12091424 Publication Date 9/17/2024 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP5
Synonyms:
51 kDa FK506-binding protein | 51 kDa FKBP | 54 kDa progesterone receptor-associated immunophilin | Androgen-regulated protein 6 | FF1 antigen | FK506-binding protein 5 | FKBP-5 | FKBP-51 | FKBP54 | HSP90-binding immunophilin | PPIase FKBP5 | Rotamase | p54 | FKBP5_HUMAN | FKBP5 | AIG6 | FKBP51
Type:
PROTEIN
Mol. Mass.:
51207.06
Organism:
Human
Description:
ChEMBL_952910
Residue:
457
Sequence:
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
  
Inhibitor
Name:
BDBM50088378
Synonyms:
CHEBI:68478 | Afinitor | Afinitor Disperz | Everolimus | RAD001 | Zortress | US12091424, Example RAD001
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: