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Target
Caspase-8
Ligand
BDBM10352
Substrate
Caspase-8 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
IC50
>50000±n/a nM
Citation
 Chu, W; Zhang, J; Zeng, C; Rothfuss, J; Tu, Z; Chu, Y; Reichert, DE; Welch, MJ; Mach, RH N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J Med Chem 48:7637-47 (2005) [PubMed]  Article 
Target
Name:
Caspase-8
Synonyms:
Caspase | Caspase-8 subunit p18 | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CASP-8 | Caspase-8 subunit p10 | MACH | FADD-homologous ICE/CED-3-like protease | FLICE | ICE-like apoptotic protease 5 | CAP4 | MORT1-associated CED-3 homolog | FADD-like ICE | CASP8_HUMAN | CASP8 | MCH5
Type:
Enzyme
Mol. Mass.:
55373.89
Organism:
Human
Description:
Q14790
Residue:
479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
  
Inhibitor
Name:
BDBM10352
Synonyms:
1-{[4-(methylsulfanyl)phenyl]methyl}-5-{[(2S)-2-[(pyridin-3-yloxy)methyl]pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | 1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione | Pyridine Analogue 21d
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-8 Fluorogenic Substrate
Synonyms:
Ac-IETD-AMC
Type:
Peptide
Mol. Mass.:
1673.49
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
16
Sequence:
ACILEGLTHRASPAMC