Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM313789
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
<100±n/a nM
Citation
 Burns, C; Garnier, J; Sharp, PP; Feutrill, J; Cuzzupe, A Benzodiazepines as bromodomain inhibitors US Patent  US10167292 Publication Date 1/1/2019 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | BRD4_HUMAN | BRD4 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Human
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM313789
Synonyms:
US10167292, Example 33
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccc(F)cc1 |r|
Structure:
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