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Target
Caspase-9
Ligand
BDBM160808
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity of Caspase
IC50
>3330±n/a nM
Citation
 Ahlfors, J; Mekouar, K Selective caspase inhibitors and uses thereof US Patent  US10167313 Publication Date 1/1/2019 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 3 | caspase-9 isoform alpha preproprotein | Caspase 9 | CASP-9 | ICE-like apoptotic protease 6 | CASP9_HUMAN | CASP9 | MCH6 | Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Human
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM160808
Synonyms:
US9045524, 76 | US10167313, Compound 76
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)\C=C\S(C)(=O)=O |r|
Structure:
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