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Target
Amine oxidase
Ligand
BDBM11018
Substrate
BDBM11019
Meas. Tech.
MAO Inhibition Assay
pH
7.4000±n/a
Temperature
298.1500±n/a K
Ki
1400±n/a nM
Citation
 Hubalek, F; Binda, C; Khalil, A; Li, M; Mattevi, A; Castagnoli, N; Edmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem 280:15761-6 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase
Synonyms:
Amine oxidase (flavin-containing) B | MAO-B | Monoamine Oxidase Type B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58481.43
Organism:
Horse
Description:
Mitochondrial preparation.
Residue:
520
Sequence:
MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTVRNQNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKAKSYPFRGPFPPAWNPIAYLDHNNLWRTMDDMGREIPSDAPWKAPLAEEWDYMTMKELLDKICWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFLGGSGQVSERIMDLLGDRVKLERPVTHIDQTGEHVLVETLNHEVYEAKYVISAVPPILGMKIHFKPPLPMMRNQLITRVPLGSVIKCMVYYKEPFWRKKDYCGTMIIEGEEAPIAYTLDDTKPDGSYAAIMGFILSHKARKLARLTKEERLKKLCELYAKVLGSQEALQPVHYEEKNWCEEQYSGGCYTTYFPPGIMTQYGRVLRQPVGRIYFAGTETATHWSGYMEGAVEAGERAAREILHALGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSAAALGFLAHKRGLLVRA
  
Inhibitor
Name:
BDBM11018
Synonyms:
2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine-4,6-dione | 8-(3-chlorostyryl)caffeine (CSC)
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O2
Mol. Mass.:
329.09
SMILES:
CC1c2nc(\C=C\c3cccc(Cl)c3)n(C)c2C(=O)N(C)C1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM11019
Synonyms:
1-methyl-4-(1-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine | 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine | MMTP
Type:
Small organic molecule
Emp. Form.:
C11H16N2
Mol. Mass.:
176.13
SMILES:
CN1CCC(=CC1)c1cccn1C |c:4|
Structure:
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