Reaction Details Report a problem with these data
Target
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D]
Ligand
BDBM5544
Substrate
Histone H1
Meas. Tech.
CDK Inhibition Assay
pH
7.5000±n/a
Temperature
303.1500±n/a K
IC50
103±n/a nM
Citation
 Pratt, DJ; Bentley, J; Jewsbury, P; Boyle, FT; Endicott, JA; Noble, ME Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity. J Med Chem 49:5470-7 (2006) [PubMed]  Article 
Target
Name:
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D]
Synonyms:
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-A2 [171-432]
Synonyms:
CCNA2_HUMAN | CCNA2 | CCN1 | CCNA | cyclin A2
Type:
Enzyme Subunit
Mol. Mass.:
30018.91
Organism:
Human
Description:
cyclin A2 is a c-terminal cyclin A fragment encoding residues 171-432.
Residue:
262
Sequence:
SVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
  
Component 2
Name:
Cyclin-dependent kinase 2 [F82H,L83V,H84D]
Synonyms:
CDK2_HUMAN | CDK2 | CDKN2 | Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D)
Type:
Enzyme Subunit
Mol. Mass.:
33891.05
Organism:
Human
Description:
P24941[F82H,L83V,H84D]
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEHVDQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM5544
Synonyms:
4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benzene-1-sulfonamide | 6-Cyclohexylmethoxy-2-(4 -sulfamoylanilino)purine | NU6102
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H1
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
Bovine
Description:
n/a
Residue:
3
Sequence:
NA