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Target
Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,L579M]
Ligand
BDBM520
Substrate
HIV Protease Chromogenic Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
pH
4.7000±n/a
Temperature
310.1500±n/a K
Ki
109±9 nM
Km
49000.0000±7000.0000 nM
Comments
kcat/Km=0.34 +/- 0.06 uM-1sec-1
Citation
 Clemente, JC; Moose, RE; Hemrajani, R; Whitford, LR; Govindasamy, L; Reutzel, R; McKenna, R; Agbandje-McKenna, M; Goodenow, MM; Dunn, BM Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry 43:12141-51 (2004) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,L579M]
Synonyms:
HIV-1 protease mutant (K20R V32I L33F M36I I54V L63P A71V V82A L90M) | HIV-1 Protease Mutant V6(54)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
The post-ritonavir therapy protease variant plus I54V mutation, which was created by site-directed mutagenesis.
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54) chain B | POL_HV1H2 | gag-pol | HIV-1 Protease Mutant V6(54) chain A
Type:
Enzyme Subunit
Mol. Mass.:
10827.15
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,L579M]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,L579M]
Synonyms:
HIV-1 Protease Mutant V6(54) chain B | POL_HV1H2 | gag-pol | HIV-1 Protease Mutant V6(54) chain A
Type:
Enzyme Subunit
Mol. Mass.:
10827.15
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587,K509R,V521I,L522F,M525I,I543V,L552P,A560V,V571A,L579M]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF
  
Inhibitor
Name:
BDBM520
Synonyms:
ABT-538 | Norvir | CHEMBL163 | 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate | RTV | Ritonavir
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV Protease Chromogenic Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1420.11
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KARVLNPHEANLG